Risk Comparison of Legal and Illegal Anti-Emetics



According to Complete Guide to Prescription & Nonprescription Drugs, Marijuana and Marinol have idendical risks. The risks associated with Compazine, Tigan and Mataclopromide vary (2002 Edition, pages 334-335. Revised and Updated by Stephen Moore, M.D.), as do the risks associated with Zofran and Kytril (obtained from the drug manufacturer as noted below).

RisksMarijuanaMarinol Compa-
zine
TiganMetaclo-
pramide
Zofran1Kytril2Dolasetron3
Year approved by FDA N/A19851980*20011980*199119991997
1. Smoking x None NoneNone None None NoneNone
2. Rapid, pounding heartbeat (common) x xx None x x NoneNone
3. Euphoria (common) x x NoneNoneNoneNoneNoneNone
4. Decreased coordination (common) x x x x x x x None
5. Red eyes, dry mouth (common) x x x NoneNoneNoneNonex
6. Dizziness, irritability, drowsiness (common) x x x x x x x x
7. Dramatic mood changes (infrequent) x x NoneNoneNoneNoneNoneNone
8. Depression, anxiety, nervousness, headache (infrequent) x x xxxxxx
9. Hallucinations (infrequent) x x NoneNonexNoneNoneNone
10. Blurred or changed vision (infrequent) x x x x none x none none
11. Fainting (rare) x x none none none none none none
12. Frequent or difficult urination (rare) x x x none x none none none
13. Convulsions (rare) x x x x x none none none
14. Shortness of breath (rare) x x x none x x x x
15. Paranoia (rare) x x none none none none none none
16. Nausea (rare)x x x none x none x none
17. Loss of appetite (rare) x x x none x none x none
18. Dizziness when standing or after sitting/lying (rare) x x x x x x x x
19. Diarrhea (rare) x x none x x x x x
20. Comanone none x x none none none none
21. Seizurenone none x x x x none none
22. Rashnone none none x x none none x
23. Frequent Vomitingnone none none x none none x none
24. Chest painnone none none nonenone none none x
25. Constipationnone none none nonenone none none x
1 Information on Zofran obtained from Glaxo Wellcome website 2-27-02
2 Information on Kytril obtained from Roche Laboratories website 2-27-02
3 Information on Dolasetron (Anzemet) obtained from official dolasetron website (www.dolasetron.com) 7/17/03