Harold Kalant, MD, PhD, Professor Emeritus at the University of Toronto, and Amy J. Porath-Waller, PhD, Director of Research & Policy at the Canadian Centre on Substance Abuse, stated in their 2012 report "Clearing the Smoke on Cannabis: Medical Use of Cannabis and Cannabinoids," available at www.ccsa.ca:

“There is sound evidence from animal experiments and well-designed clinical trials involving humans that cannabis and cannabinoids are effective for the relief of nausea/vomiting and certain types of pain, as well as for the stimulation of appetite. However, the evidence to date does not indicate that they are the best drugs to use for these purposes. Many studies have shown, for example, that for treating nausea and vomiting, cannabinoids are more effective than older medications such as phenothiazines (e.g., Stemetil┬«) or antihistaminics (e.g., Dramamine┬«), but appear to be less effective than newer antinauseants such as ondansetron and similar drugs.”