Distribution of Cannabinoid Receptors (CB1) in the Brain. The Feeling of Being High Comes from THC Activating CB1 Receptors. Source: www.scienceblogs.com/corpuscallosum, July 21, 2007
Drug Strategy and Controlled Substances Programme, a program of Health Canada, stated on a page titled "All About Marijuana" on its website (accessed Jan. 2, 2007)
“How does marijuana actually work? Why does it make you high?
This topic can be a bit complicated, with lots of detail about how the active ingredients of marijuana affect the inner-workings of the brain […] let’s just say that cannabis has what are called psychoactive chemicals, the main one being ‘tetrahydrocannabinol’ or THC for short.
When you smoke a joint, the THC goes into your lungs, then into your heart which pumps it into your bloodstream which then takes it directly to your brain. When you smoke marijuana, it only takes a few minutes for the THC to get to your brain, whereas if you eat it, it would take a little longer because it has to pass through your digestive system first.
Once it’s in your brain, the THC activates what are called ‘receptors,’ and gives you the feeling of being high. In short, marijuana changes the physical and chemical balance in your brain and this is what people refer to as a ‘high’.”Jan. 2, 2007