The Institute of Medicine published in its Mar. 1999 report titled “Marijuana and Medicine: Assessing the Science Base”:

“The psychological effects of cannabinoids, such as anxiety reduction, sedation, and euphoria, can influence their potential therapeutic value.

Those effects are potentially undesirable in some patients and situations and beneficial in others. In addition, psychological effects can complicate the interpretation of other aspects of the drug’s effect.”

Mar. 1999 - “Marijuana and Medicine: Assessing the Science Base”