Denis Petro, MD, Founding Director of Patients Out of Time, stated in his 1997 paper "Seizure Disorders" published in Cannabis in Medical Practice - A Legal, Historical and Pharmacological Overview of the Therapeutic Use of Marijuana:

“Seizures have been reported in patients after they used THC [Marinol] to control nausea in cancer chemotherapy. Since THC is psychoactive in many animal studies and is associated with other adverse effects, THC can be eliminated from consideration as a potential candidate for treatment of epilepsy.

In animal seizure models CBD [cannabidiol] has been shown to have anticonvulsant properties with potential in grand mal, cortical focal, and complex partial seizures….

In summary, a review of the literature documents some reports of the effects of marijuana in seizure disorders. The data concerning marijuana is mixed with both positive and negative reports. The scientifice evidence in support of CBC [cannabidiol] is stronger based on both preclinical and clinical studies.”