Ethan Russo, MD, Senior Medical Advisor at the Cannabinoid Research Institute, wrote the following in the Dec. 2002 issue of Cannabis Health:

“A surprising number of people so afflicted [with bi-polar disorder] have independently made the discovery that cannabis has improved their conditions, whether the mania or depression. It may also reduce side effects of other drugs used in its treatment, such as Lithium, Carbamazepine (Tegretol) or Valproate (Depakote).

No doubt, cannabis is affecting the balance of neurotransmitters that are at the basis for this disorder.

Endocannabinoids seem to be intimately involved in emotional regulation mechanisms in the limbic system. Because THC and other chemicals in cannabis mimic our own internal biochemistry, they may help replace what is missing.”

Dec. 2002